List of models

knitr::kable(modeldb[, c("name", "description")])
name description
PK_1cmt One compartment PK model with linear clearance
PK_1cmt_des One compartment PK model with linear clearance using differential equations
PK_2cmt Two compartment PK model with linear clearance
PK_2cmt_des Two compartment PK model with linear clearance using differential equations
PK_2cmt_no_depot Two compartment PK model with linear clearance using differential equations
PK_2cmt_tdcl_des Two compartment PK model with time-dependent clearance using differential equations (structured like nivolumab PK model)
PK_3cmt Three compartment PK model with linear clearance
PK_3cmt_des Three compartment PK model with linear clearance using differential equations
phenylalanine_charbonneau_2021 Phenylalanine model for absorption and metabolism in healthy subjects and patients with PKU
indirect_0cpt_transitEx Two compartment PK model with Michealis-Menten clearance using differential equations
indirect_1cpt_inhi_kin One compartment indirect response model with inhibition of kin.
indirect_1cpt_inhi_kin_CLV One compartment indirect response model with inhibition of kin.
indirect_1cpt_inhi_kin_r0rmaxcrmax One compartment indirect response model with inhibition of kin.
indirect_1cpt_inhi_kout One compartment indirect response model with inhibition of kout.
indirect_1cpt_inhi_kout_CLV One compartment indirect response model with inhibition of kout.
indirect_1cpt_inhi_kout_r0rmaxcrmax One compartment indirect response model with inhibition of kout.
indirect_1cpt_stim_kin One compartment indirect response model with stimulation of kin.Parameterized using rate cosntants
indirect_1cpt_stim_kin_CLV One compartment indirect response model with stimulation of kin.
indirect_1cpt_stim_kin_r0rmaxcrmax One compartment indirect response model with stimulation of kin.
indirect_1cpt_stim_kout One compartment indirect response model with stimulation of kout.Parameterized using rate cosntants
indirect_1cpt_stim_kout_CLV One compartment indirect response model with stimulation of kout.
indirect_1cpt_stim_kout_r0rmaxcrmax One compartment indirect response model with stimulation of kout.
indirect_circ_1cpt_inhi_kin_kin_t One compartment indirect response model with inhibition of kin and circadian kin_t.
indirect_circ_1cpt_inhi_kin_kout_t One compartment indirect response model with inhibition of kin and circadian kin_t.
indirect_circ_1cpt_inhi_kout_kin_t One compartment indirect response model with inhibition of kout and circadian kin_t.
indirect_circ_1cpt_inhi_kout_kout_t One compartment indirect response model with inhibition of kout and circadian kin_t.
indirect_circ_1cpt_stim_kin_kin_t One compartment indirect response model with stimulation of kin and circadian kin_t.Parameterized using rate cosntants
indirect_circ_1cpt_stim_kin_kout_t One compartment indirect response model with stimulation of kin and circadian kout_t.Parameterized using rate constants
indirect_circ_1cpt_stim_kout_kin_t One compartment indirect response model with stimulation of kout and circadian kin_t.Parameterized using rate cosntants
indirect_circ_1cpt_stim_kout_kout_t One compartment indirect response model with stimulation of kout and circadian kout_t.Parameterized using rate cosntants
indirect_prec_1cpt_inhi_CLV One compartment precursor-dependent indirect response model with inhibition of drug response. Parameterized with clearance and volume. (effect).
indirect_prec_1cpt_inhi_r0rmaxcrmax One compartment precursor-dependent indirect response model with inhibition of drug response (effect).
indirect_prec_1cpt_stim_CLV One compartment precursor-dependent indirect response model with inhibition of drug response (effect). Parameterized with clearance and volume
indirect_prec_1cpt_stim_r0rmaxcrmax One compartment precursor-dependent indirect response model with inhibition of drug response (effect). Parameterized with clearance and volume
PK_2cmt_mAb_Davda_2014 Two compartment PK model with linear clearance for average monoclonal antibodies (Davda 2014)
PK_double_sim_01 PK double absorption model with simultaneous zero order and first order absorptions
PK_double_sim_10 PK double absorption model with simultaneous first order and zero order absorptions
PK_double_sim_11 PK double absorption model with simultaneous first order absorptions
CarlssonPetri_2021_liraglutide Liraglutide PK model in adolescents (Carlsson Petri 2021)
Cirincione_2017_exenatide Exenatide immediate-release PK model (Cirincione 2017)
Kovalenko_2020_dupilumab Dupilumab PK model (Kovalenko 2020)
Soehoel_2022_tralokinumab Tralokinumab PK model (Soehoel 2022)
Zhu_2017_lebrikizumab Lebrikizumab PK model (Zhu 2017)
oncology_sdm_lobo_2002 Signal transduction model for delayed concentration effects on cancer cell growth
oncology_xenograft_simeoni_2004 Oncology tumor growth model in xenograft models
tgi_no_sat_Koch One compartment TGI model with with exponential tumor growth, without saturation.
tgi_no_sat_expo One compartment TGI model with with exponential tumor growth, without saturation.
tgi_no_sat_linear One compartment TGI model with with linear tumor growth, without saturation.
tgi_no_sat_powerLaw One compartment TGI model with with exponential tumor growth, without saturation.
tgi_sat_VonBertalanffy One compartment TGI model where tumor growth is limited by a loss term, with saturation.
tgi_sat_genVonBertalanffy One compartment TGI model where tumor growth is limited by a loss term, with saturation.
tgi_sat_logistic One compartment TGI model with with exponential tumor growth that decelerates linearly, with saturation.