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*                           nimo.mlxtran                                       *
*                           May 18, 2022 at 01:57:00                           *
*                           Monolix version : 2021R1                           *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)
cl_pop    :                         0.0027   0.00148      54.7
v1_pop    :                           1.51     0.256        17
Q_pop     :                        0.00526  0.000978      18.6
v2_pop    :                           82.9      47.1      56.8
kss_pop   :                              0       nan       nan
kint_pop  :                       2.85e-06        14  4.92e+08
ksyn_pop  :                       1.11e-06    0.0107  9.61e+05
kdeg_pop  :                           1.07  3.31e+04  3.09e+06

Standard Deviation of the Random Effects -
omega_cl  :                            1.2     0.278      23.2
omega_v1  :                          0.533     0.131      24.6
omega_kss :                           10.7       nan       nan

Error Model Parameters -------------------
lnorm__sd :                          0.694    0.0285       4.1

Elapsed time (seconds):    3e+02
CPU time     (seconds):  6.7e+02
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
             min        Q1    median        Q3       max
cl   :  0.000382   0.00111   0.00214   0.00637    0.0171
v1   :     0.628      1.04      1.47      2.33      2.97
Q    :   0.00526   0.00526   0.00526   0.00526   0.00526
v2   :      82.9      82.9      82.9      82.9      82.9
kss  :         0         0         0         0  2.85e-16
kint :  2.85e-06  2.85e-06  2.85e-06  2.85e-06  2.85e-06
ksyn :  1.11e-06  1.11e-06  1.11e-06  1.11e-06  1.11e-06
kdeg :      1.07      1.07      1.07      1.07      1.07

Elapsed time (seconds):      4.7
CPU time     (seconds):       11
Iterations:       74 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
             min        Q1    median        Q3       max
cl   :  0.000522   0.00146   0.00267   0.00679    0.0176
v1   :     0.645      1.04      1.49      2.35      2.98
Q    :   0.00526   0.00526   0.00526   0.00526   0.00526
v2   :      82.9      82.9      82.9      82.9      82.9
kss  :         0         0         0         0         0
kint :  2.85e-06  2.85e-06  2.85e-06  2.85e-06  2.85e-06
ksyn :  1.11e-06  1.11e-06  1.11e-06  1.11e-06  1.11e-06
kdeg :      1.07      1.07      1.07      1.07      1.07

Elapsed time (seconds):      0.1
CPU time     (seconds):        0

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Linearization -------------------

Correlation Matrix :
   cl_pop         1
   v1_pop  0.013114         1
    Q_pop  -0.70955  0.028343         1
   v2_pop  -0.37609   0.06591   0.46156         1
  kss_pop       nan       nan       nan       nan       nan
 kint_pop 0.0034952  0.019521  0.045048    0.2955       nan         1
 ksyn_pop  -0.19487-0.0037451   0.14028  -0.50047       nan   -0.3009         1
 kdeg_pop -0.016482  0.011877    0.0705   0.33119       nan    0.6833  -0.28338         1
 omega_cl         0         0         0         0       nan         0         0         0         1
 omega_v1         0         0         0         0       nan         0         0         0-0.0043481         1
omega_kss       nan       nan       nan       nan       nan       nan       nan       nan       nan       nan       nan
lnorm__sd         0         0         0         0       nan         0         0         0 -0.020372 -0.033274       nan         1

WARNING : Impossible to compute the eigen values of the correlation matrix.

Elapsed time (seconds):    0.039
CPU time     (seconds):        0

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 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                           (lin)
-2 x log-likelihood                       (OFV) :        3439.59
Akaike Information Criteria               (AIC) :        3463.59
Corrected Bayesian Information Criteria  (BICc) :        3498.98
Bayesian Information Criteria             (BIC) :        3469.40

Elapsed time                          (seconds) :           0.00
CPU time                              (seconds) :           0.00

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 12
Number of observations (DV): 321
Number of doses: 120

